Abstract #1251

ZTE MRI for attenuation correction in PET/MR: performance in a large cohort of cognitive disorder patients

Maya Khalifé¹, Brian Sgard^2,3, Arthur Bouchut¹, Brice Fernandez⁴, Marine Soret², Gaspar Delso⁵, Marie-Odile Habert^2,3, and Aurélie Kas^2,3

¹Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France, ²Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière C. Foix, Paris, France, ³Laboratoire d’Imagerie Biomédicale, Sorbonne Universités, UPMC Univ Paris 06, Inserm U 1146, CNRS UMR 7371, Paris, France, ⁴Applications and Workflow, GE Healthcare, Orsay, France, ⁵Applications and Workflow, GE Healthcare, Cambridge, United Kingdom

Several attenuation correction (AC) methods based on Zero Echo Time (ZTE) MRI are available in brain PET/MR. However, most of them were evaluated in healthy subjects or in patients without apparent brain disease. In this work, we investigated ZTE-AC in a 50-patient cohort imaged for cognitive disorders and we compared its performance with default atlas-AC and reference CT-based AC. The impact of the two AC methods (ZTE-AC and atlas-AC) was evaluated and compared to reference CT-AC, using a Volume of Interest (VOI) analysis and voxelwise group comparison between patients with normal cortical metabolism vs. metabolic pattern suggestive of Alzheimer’s disease.

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