Alzheimer’s disease is the most widespread cause of dementia and constitutes one of the biggest challenges for society. Among dominant mechanisms of the disease is the abnormal accumulation of the protein tau leading to tauopathy. In this study we explored in vivo the longitudinal evolution of the brain functional connectome, in the Thy-Tau22 mouse, a model of tauopathy. We used resting-state functional MRI in correlation with behavioral analysis to show the remodeling functional circuitry over-time including default mode network and memory networks in transgenic mice.
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