Abstract #1207

Motion-robust sub-millimeter isotropic diffusion imaging through Motion Corrected Generalized Slice Dithered Enhanced Resolution (MC-gSlider) acquisition

Fuyixue Wang^1,2, Berkin Bilgic¹, Zijing Dong³, Mary Katherine Manhard¹, Ned Ohringer¹, Bo Zhao¹, Melissa Haskell^1,4, Stephen F. Cauley¹, Qiuyun Fan¹, Thomas Witzel¹, Elfar Adalsteinsson^2,5, Lawrence L. Wald^1,2, and Kawin Setsompop^1,2

¹A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ³Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ⁴Graduate Program in Biophysics, Harvard University, Cambridge, MA, United States, ⁵Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

gSlider is an SNR-efficient acquisition technique for high-resolution diffusion imaging (dMRI). However, subject motion is inevitable during long scans in high-resolution dMRI, leading to potential for artifacts and blurring. In this study, Motion Corrected gSlider (MC-gSlider) is proposed to obtain high-quality dMRI in the presence of large in-plane and through-plane motion, without use of a navigator. A motion-aware reconstruction with spatially-adaptive regularization is developed to achieve good reconstruction, even under difficult through-plane motions. MC-gSlider was demonstrated in-vivo to provide motion-robust, sub-millimeter isotropic dMRI with a motion correction rate of 2s, allowing for good reconstruction in the presence of large motions.

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