Abstract #1204

Fast Distortion-Free Diffusion Imaging using “tilted-CAIPI” PSF-EPI

Zijing Dong¹, Fuyixue Wang^2,3, Timothy G. Reese², Mary Kate Manhard², Berkin Bilgic², Lawrence L. Wald^2,3, Hua Guo¹, and Kawin Setsompop^2,3

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Single-shot EPI is widely used for diffusion imaging, but suffers from susceptibility-induced distortion and T₂* blurring, which limit its resolution and ability to detect detailed structures. PSF-encoded EPI with an added 2D-navigator has recently been developed to allow distortion- and blurring- free diffusion imaging. However, the extremely long acquisition of PSF-EPI makes it impractical for high angular resolution diffusion imaging. In this work, PSF-EPI is accelerated by >20x using a novel “tilted-CAIPI” approach, along with self-navigation strategy. This has enabled distortion- and blurring-free diffusion imaging at 1.2mm isotropic to be acquired with 48 diffusion directions in 21-minutes for whole-brain.

This abstract and the presentation materials are available to members only; a login is required.

Join Here