Abstract #1194

Intra-vascular, MRI-Guided, perivascular ultrasound ablation with thermometric monitoring of therapy delivery

Xiaoyang Liu^1,2, Nicholas Ellens^2,3, Emery Williams⁴, Clif Burdette⁴, Parag Karmarkar², and Paul Bottomley^1,2

¹Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, ²Russell H. Morgan Dept. of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Acertara Acoustic Laboratories, Longmont, CO, United States, ⁴Acoustic MedSystems, Inc, Champaign, IL, United States

Vessel invasion from a tumor is a major challenge for both surgical resection and extracorporeal HIFU ablation. Conceivably, an intravascular ultrasound ablation catheter combined with an intravascular high-resolution MRI coil could precisely target and monitor of peri-vascular therapy delivery that preserves the vessel wall via MRI thermometry. We present results from an intra-vascular 3T ultrasound ablation/MRI antenna probe that document MRI thermometry-based thermal dosage and lesion formation in porcine liver and chicken specimens with vessel wall preservation. A simple motion-correction method that employs the antenna’s intrinsic sensitivity profile as a navigator for thermometry is tested in vivo.

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