Abstract #1166

Radiomics subtyping improves 5-year disease free survival prediction beyond key clinical and radiological characteristics in patients with locally advanced rectal cancer (LARC)

Ke Nie¹, Peng Hu², Fei Peng³, Tingyu Mao⁴, Xiao Wang¹, Ning Yue¹, and Jihong Sun²

¹Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States, ²Department of Radiological Sciences, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Institute of Translational Medicine，Zhejiang University, Hangzhou, China, ⁴Department of Electrical Engineering, Columbia University, New York, NY, United States

In this study, we have identified an 11-feature set from a large panel of radiomics signature (5248 features from pre-operative T1w, T2w, DCE and DWI images) that allows prediction of 5-year disease free survival of locally advanced rectal cancer patients underwent surgical resection. The selected radiomics signature demonstrates improved performance compared with that of established clinical and radiological risk models. The results were tested and validated on a consecutive 165-patient cohort with an average of 54±20 months follow-ups.

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