Treatment for women with locally advanced breast cancer (LABC) is determined with inadequate knowledge of the long-term outcome. We evaluated the prognostic value of textural features derived from pre-treatment CE-MRI in 55 LABC patients scheduled for neoadjuvant chemotherapy. Using overall survival at 7-years follow-up as endpoint, textural features derived from post-contrast pre-treatment images were significantly different. Using all textural features as input for multivariate analysis, we achieved a classification accuracy of 72% (p<0.001), which increased to 78% when including traditional prognostic factors (p<0.001). Textural features provide prognostic information, which can complement the stratification of patients to treatment.
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