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Abstract #1161

Susceptibility contrast-MRI predicts response to the vascular endothelial growth factor receptor inhibitor cediranib in the Th-MYCN model of neuroblastoma

Konstantinos Zormpas-Petridis1, Matthew D. Blackledge1, Louis Chesler2, Yinyin Yuan3, Simon P. Robinson1, and Yann Jamin1

1Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 2Division of Clinical Studies, Institute of Cancer Research, London, United Kingdom, 3Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom

In this study we demonstrate that fractional blood volume, measured by susceptibility contrast-MRI, predicts response to the vascular endothelial growth factor receptor inhibitor cediranib in the Th-MYCN genetically-engineered mouse model of neuroblastoma.

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