Abstract #1153

Investigation of Anterior Cingulate Cortex γ-Aminobutyric Acid and Glutamate-Glutamine Levels in Patients with Obsessive-Compulsive Disorder by Proton Magnetic Resonance Spectroscopy

Yan Li¹, Naying He¹, Hongmin Xv¹, Zhijia Jin¹, ChenCheng Zhang², Weibo Chen³, Yansong Zhao⁴, Richard A. E. Edden⁵, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China, ²Department of Functional Neurosurgery, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China, ³Philips Healthcare, Shanghai, China, ⁴Philips Healthcare, Cleveland, OH, United States, ⁵Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

The aim of this study is to evaluate the feasibility of ¹H-MR edited spectroscopy for the detection of cerebral abnormalities in Obsessive-Compulsive Disorder (OCD) patients. Twenty-three OCD patients and Twenty-four normal controls (NC) underwent MRS. The γ-Aminobutyric Acid (GABA) and Glutamate-Glutamine (Glx) level of anterior cingulate cortex (ACC) was quantified based on the GANNET 2.0 software. Differences of GABA and Glx levels between two groups were analyzed using independent two sample t-test analysis. Relative to NC group, OCD patients had higher GABA concentration in the ACC (p<0.05), but had no significant difference in ACC Glx levels. To our knowledge, this study presents the first GABA concentration measurements within ACC in OCD patients. Our results suggested that GABA and Glx levels in the ACC might be promising diagnostic and monitoring biomarker for OCD.

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