Hippocampus plays a prominent role in central nervous system functions. It receives convergent projections and sends reciprocal divergent projections, forming an interactive cortico-hippocampal-cortical network. However, the precise brain-wide functional organization of different hippocampal activities along dorsoventral axis remains unknown. Using optogenetic fMRI, we revealed that functional organization of low frequency hippocampal activities along dorsoventral axis exhibits a gradual change from regions mainly involved in cognition and sensory processing to regions also involved in motor control and anxiety-related behavior. Additionally, hippocampal activities generally transit from long-range propagation to downstream cortical/subcortical regions to local intra-hippocampal propagation with increasing frequencies.
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