In vivo MRI detection of early β-amyloid pathologies targeted by curcumin-conjugated magnetic nanoparticles
Celia M. Dong1,2, Anthea To1,2, Eddie C. Wong1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China
Early state β-amyloid oligomers (AβOs) and late stage Aβ plaques are the pathological hallmarks of Alzheimer's disease (AD) brains, and they can be targeted by curcumin. We have recently designed and synthesized a new curcumin-conjugated magnetic nanoparticles (Cur-MNPs) to target these Aβ pathologies. In this study, we aimed to assess this novel Cur-MNPs based MRI contrast agent for its in vivo ability to detect and visualize the Aβ pathologies during both very early and late stage of AD progression in AD mouse models.
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