Abstract #1070

Multi-Excitation MRE in Aging Human Brain

Aaron T Anderson^1,2, Curtis L Johnson³, Tracey M Wszalek², Bradley P Sutton^2,4, Elijah EW Van Houten⁵, and John G Georgiadis⁶

¹Mechanical Science & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Biomedical Engineering, University of Delaware, Newark, DE, United States, ⁴Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Département de génie mécanique, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States

The adult aging process affects human brains in different ways and becomes more prone to neurodegenerative diseases. MRE has shown it’s sensitivity to both changes within healthy brains and identifying biomarkers in diseased brains. This study builds on previous MRE aging research and adds higher-resolution, full-coverage MRE imaging and the ability to identify tissue anisotropy, or lack thereof, with the multi-excitation experiment. We were able to identify important anisotropic differences in the loss modulus for some white matter (WM) regions within the young group and a loss of group-level anisotropy in the select WM regions in the older group.

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