Abstract #1027

Development of a diffusion-weighted SSFP acquisition and processing pipeline to quantify the diffusion properties of the post-mortem ALS brain at 7T

Benjamin Tendler¹, Saad Jbabdi¹, Sean Foxley², Menuka Pallebage-Gamarallage³, Moises Hernandez Fernandez¹, Ricarda Menke¹, Thomas Nichols⁴, Martin Turner³, Olaf Ansorge³, and Karla Miller¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Department of Radiology, University of Chicago, Chicago, IL, United States, ³Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁴Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

An acquisition and processing pipeline is outlined to quantify the diffusion properties of post-mortem brain samples from diffusion-weighted steady-state free precession (dwSSFP), as part of an ongoing project examining the impact of amyotrophic lateral sclerosis (ALS) on the human brain. Preliminary results are presented comparing the post-mortem diffusion properties of control brains and patients diagnosed with ALS over the corpus callosum. Clear trends are observed within the results, with a maximum deviation between control and ALS brains observed within callosal regions connecting the motor cortices in the two hemispheres.

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