Whole-Tumor Histogram and Texture Analyses of Diffusion Tensor Imaging for Evaluation of IDH1 Mutation and 1p/19q Codeletion Status in WHO grade II gliomas

We analyzed the histogram and texture features of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) based on entire tumor to determine isocitrate dehydrogenase 1 (IDH1) mutation and 1p/19q codeletion status in WHO grade II gliomas. Regions of interest were drawn on ADC and FA maps of 93 grade II gliomas. Histogram and texture analyses were performed. The areas under the curve (AUC) for IDH1-wildtype prediction was 0.853, and AUC for 1p/19q codeletion prediction was 0.807. The whole-tumor histogram and texture features of ADC and FA maps are useful in predicting the molecular status in WHO grade II gliomas.