Abstract #0956

Magnetic Resonance Spectroscopy markers of survival in paediatric brain tumours: A 3T Multi-Centre investigation

Ben Babourina-Brooks^1,2, Lesley MacPherson², Laurence J Abernethy³, Theodoros N Arvanitis^2,4, Simon Bailey⁵, Nigel P Davies^1,2,6, Daniel Rodriguez Gutierrez ^7,8,9, Tim Jaspan ^7,10, Dipayan Mitra¹¹, Paul S Morgan^7,9,10, Barry Pizer ¹², Richard G. Grundy ⁷, Dorothee P Auer^7,8,10, and Andrew C Peet^1,2

¹University of Birmingham, Birmingham, United Kingdom, ²Birmingham children's hospital, Birmingham, United Kingdom, ³Department of Radiology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁴Institute of Digital Healthcare, WMG, University of Warwick, Coventry, United Kingdom, ⁵Paediatric Oncology Department, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom, ⁶Department of Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁷The Children‘s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, ⁸Radiological Sciences, Department of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, ⁹Medical Physics, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, ¹⁰Neuroradiology, Nottingham University Hospital, Queen’s Medical Centre, Nottingham, United Kingdom, ¹¹Neuroradiology Department, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom, ¹²Department of Paediatric Oncology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom

Brain tumours have a high mortality rate and are the most common solid tumour of childhood. The non-invasive imaging technique, MRS, measures tumour metabolites which can provide additional prognostic information to aid in clinical management. MRS metabolites Glycine, Scyllo-Inositol, NAA and Lipids have been associated with prognosis for pediatric brain tumour patients in a single centre 1.5T study. This study aimed to validate these MRS survival markers in a 3T multicentre setting. In this preliminary study Lipids were validated as a survival marker across childhood brain tumours.

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