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Abstract #0914

Ferumoxytol-Enhanced 4D MUSIC: Early Multi-Center Experience on Value-Added Magnetic Resonance Imaging in Pediatric Congenital Heart Disease

Kim-Lien Nguyen1, Cynthia K. Rigsby2, Kevin K. Whitehead3, Mark L. Fogel3, Peng Hu4, and J. Paul Finn5

1Department of Radiological Sciences and Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, 2Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 3Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 4Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 5Department of Radiological Sciences and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

The value of MRI in congenital heart disease (CHD) is well-recognized. However, high time overhead and the requirement for expert oversight of image acquisition impede its more widespread use. Ferumoxytol-enhanced 4-dimensional multiphase imaging with contrast (4D-MUSIC) is a cardiac phase-resolved MR technique that generates highly detailed images under controlled ventilation. Our early multi-center experience demonstrates that 4D-MUSIC provides value-added imaging in CHD by shortening the examination time, simplifying the imaging protocol, and providing reliable, gadolinium-free, high spatial resolution, cardiac phase-resolved images. When combined with locally available velocity mapping, 4D-MUSIC enables comprehensive imaging of complex CHD in less than 40 minutes.

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