Abstract #0885

Diffusion Time Dependence of NODDI in in vivo Human White Matter

Masaaki Hori¹, Kouhei Kamiya², Katsutoshi Murata³, Thorsten Feiweier⁴, Issei Fukunaga¹, Akifumi Hagiwara^1,2, Ryusuke Irie^1,2, Christina Andica¹, Tomoko Maekawa^1,2, Saori Koshino^1,2, Koji Kamagata¹, Kanako Kunishima Kumamaru¹, Michimasa Suzuki¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Siemens Japan K.K., Tokyo, Japan, ⁴Siemens Healthcare GmbH, Erlangen, Germany

We investigated the diffusion time dependency of diffusion metrics, especially ICVF and INVF, compared with ADC using an oscillating gradient spin-echo sequence in in vivo human white matter at 3T. Our results show that the change ratio of both ICVF and INVF indicate similar tendency in the same white matter locations, with or without diffusivity calculation. Moreover, with higher oscillating frequency, ICVF decreased but ISOVF stayed almost unchanged, indicating that the rate of ICVF and the extra-cellular component may change with oscillating frequency beside the unchanged isotropic water component.

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