Abstract #0882

Cross-vendor harmonization of T2-Relaxation-Under-Spin-Tagging (TRUST) MRI for the assessment of cerebral venous oxygenation

Dengrong Jiang¹, Peiying Liu², Yang Li^2,3, Deng Mao^2,3, Cuimei Xu², and Hanzhang Lu^1,2,4

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Cerebral venous oxygenation (Y_v) is an important physiological parameter and has potential clinical application in many diseases. T₂-relaxation-under-spin-tagging (TRUST) is a commonly used MRI method to measure Y_v. Harmonization of TRUST across MRI vendors is important for dissemination and multi-center studies of brain oxygenation as a disease biomarker. In this work, we harmonized TRUST pulse sequence components and imaging parameters across two major MRI vendors, Philips and Siemens. We showed that Y_v measured on the two vendors were highly compatible and strongly correlated, had excellent reproducibility, and can reliably detect oxygenation changes associated with physiological challenges on both scanners.

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