We applied a novel time-regression analysis to hypercapnic BOLD imaging data in a cohort of moyamoya patients with progressive steno-occlusion of the intracranial arteries before and after surgical revascularization with the overall goal of elucidating gray and white matter differences in cerebrovascular reactivity (CVR)-weighted responses and vascular compliance time measures. We observed differences between gray and white matter reactivity time delays, as well as depth-dependent differences in reactivity and time delays within the white matter. Additionally, we observed that the improvement in both white and gray matter hemodynamics following surgical revascularization was closely related to pre-surgical CVR-weighted metrics.
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