An important role for cilia in congenital heart disease (CHD) pathogenesis has been seen in mouse model of CHD. There is a high prevalence of motile respiratory cilia dysfunction in human CHD patients. In this study, we investigate whether abnormal respiratory cilia motion in preadolescent CHD patients may be correlated with alterations in macroscopic CSF flow dynamics and poor executive cognitive function using phase contrast imaging. We show disturbance of CSF flow dynamics is significantly correlated with neurocognitive impairment in CHD subjects.
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