Abstract #0831

MRI predicts histopathologic composition of ileal Crohn's disease.

Mathilde Wagner^1,2, Mabel Huaibin Ko³, Manjil Chatterji⁴, Cecilia Besa⁴, Joana Torres⁵, Xiaofei Zhang³, Hinaben Panchal⁵, Judy Cho⁵, Jean-Frederic Colombel⁵, Noam Harpaz³, and Bachir Taouli^2,4

¹Radiology, Pitié Salpêtrière Hospital, UPMC, Paris, France, ²Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ³Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ⁴Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ⁵Gastroenterology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

The aim of our study was to assess the value of MRI for the characterization of histopathologic tissue composition of small bowel Crohn’s disease (CD), including assessment of inflammation, fibrosis and smooth muscle hypertrophy. Our results showed that MRI-based parameters including ADC, MaRIA score and layered pattern of enhancement can predict the degree of bowel inflammation. We also showed that wall thickness measured on T2WI can distinguish prominent muscle hypertrophy from prominent fibrosis in ileal CD.

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