Abstract #0823

MR elastography and multiparametric MRI of chronic pancreatitis reversal after bariatric surgery in obese rats

Philippe Garteiser¹, Vinciane Rebours^1,2, Sabrina Doblas¹, Gwenael Pagé¹, André Bado¹, Valérie Paradis^1,3, Maude Le Gall¹, Anne Couvelard^1,4, and Bernard E Van Beers^1,5

¹UMR 1149 Center For Research on Inflammation, Inserm, Paris, France, ²Beaujon Hospital, Pancreatology, AP-HP, Clichy, France, ³Beaujon Hospital, Pathology, AP-HP, Clichy, France, ⁴Bichat Hospital, Pathology, AP-HP, Paris, France, ⁵Beaujon Hospital, Radiology, AP-HP, Clichy, France

In obesity, pancreas is affected by fatty infiltration and fibrosis. Bariatric surgery is one of the only therapies which demonstrably improves pancreas status in obesity. In the present work we investigated the mechanical properties at several frequencies, the PDFF and the T2* of pancreatic explants in an obese rat model of bariatric surgery. Bariatric surgery reversed the MRI parameters to values not significantly different than controls. MRI parameters closely matched the reference histology observations. MRE and multiparametric MRI may be used to monitor pancreatic status and treatment response in an obese rat model of bariatric surgery.

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