The purpose of this study was to assess differences in fat fraction and water diffusion between muscles in the healthy thigh and to assess differences between glucocorticoid treated patients with polymyalgia rheumatic (PMR) and healthy controls. Twenty five healthy volunteers and sixteen patients with PMR undergoing glucocorticoid treatment underwent MRI to assess muscle fat fraction and diffusion. The study found that the hamstrings have greater fat fraction and reduced diffusion compared to quadriceps in healthy individuals. Furthermore, alterations in fat fraction and diffusion parameters associated with glucocorticoid-treated PMR are more readily detectable in the hamstrings than the quadriceps.
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