A T1Rho sequence was used in a Duchenne Muscular Dystrophy mouse model characterized by increased muscle fibrosis. Significantly higher T1Rho relaxation times were found compared to wild-type mice in which fibrosis was absent. Although both T1Rho and T2 values were increased, the increase was more pronounced for T1Rho than for T2 (14.2% vs 3.6%), indicating that T1Rho is affected by other processes than those resulting in increased T2 values. These data demonstrate the potential of T1Rho to assess muscle fibrosis in vivo.
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