Abstract #0815

Water T2 mapping in fatty infiltrated thigh muscles of patients with neuromuscular diseases using a T2-prepared 3D TSE with SPAIR

Sarah Schlaeger^1,2, Dominik Weidlich¹, Elisabeth Klupp², Federica Montagnese³, Marcus Deschauer⁴, Benedikt Schoser³, Sarah Bublitz⁴, Claus Zimmer², Ernst J. Rummeny¹, Jan S. Kirschke², and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, ²Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, ³Friedrich-Baur-Institut, Ludwig Maximilian University, Munich, Germany, ⁴Department of Neurology, Technical University of Munich, Munich, Germany

In patients with neuromuscular diseases muscle water T2 is an important biomarker to monitor disease activity and therapy effectiveness. Especially, the thigh is of interest showing disease-characteristic patterns of involvement. Different T2 mapping approaches, routinely based on MESE, have been developed to minimize the effect of confounding factors. An alternative method is the T2Prep 3D-TSE combined with SPAIR. However, it remains unknown, how T2Prep 3D-TSE performs in the presence of fat. This work simulates the effect of SPAIR and T2preparation on the 3D-TSE readout in the presence of fat and compares T2Prep 3D-TSE and 2D-MESE to MRS in 34 patients.

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