Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital lobar emphysema and alpha-1 antitrypsin deficiency. Recently, a stretched-exponential-model combined with under-sampling in the imaging and diffusion directions was proposed for the evaluation of hyperpolarized gas multiple b-value diffusion-weighted MRI. The major advantage of this method is the possibility to significantly speed up the data acquisition using acceleration factors between 7 and 10. We hypothesize that this method can be extended to provide whole lung hyperpolarized gas MRI-based emphysema biomarkers including static-ventilation, T2* ADC and morphometry maps with high spatial image resolution.
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