The goal of this project is to establish advanced MRI signatures of each stage of Alzheimer’s disease (AD), including preclinical, mild cognitive impairment (MCI), and dementia stages. These advanced imaging methods will allow us to non-invasively investigate the underlying neurobiological changes that precede cognitive impairment. While structural MRI is known to change with disease progression, advanced MR imaging may provide more specific signatures of disease progression. The asymptomatic and MCI phases represent a clear potential for early intervention, and the non-invasive methods developed here may identify patients along the clinical trajectory of AD.
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