We report increase in sensitivity, specificity and accuracy of PIRADSv2 by addition of MRSI to mpMRI protocol for detection of cancer of prostate (CaP). 26 patients having a biopsy-proven CaP, were investigated at 3.0T using mpMRI including MRSI, followed by radical prostatectomy within 1 month. PIRADSv2 score for mpMRI, PIRADSv1 score for MRSI and Gleason grade group from radical prostatectomy specimens were determined. ROC curve analysis was used to determine the accuracy for cut-offs. A combination of MRSI PIRADSv1 cut-off ≥4 and PIRADSv2 cut-off ≥3 showed the best accuracy (96.2%) for CaP detection. When MRSI was added to PIRADSv2 scoring we found an improvement from 71.4% sensitivity and 91.9% specificity of PIRADSv2 to 91.8% sensitivity and 98% specificity for detecting CaP.
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