Abstract #0670

Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury

Patrik O. Wyss^1,2,3, Eveline Huber⁴, Patrick Freund^4,5,6,7, and Anke Henning^1,3,8

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland, ³Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany, ⁴Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland, ⁵Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, ⁶Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, ⁷Department of Neurophysics, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁸Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

Remote neurodegenerative changes above the level of injury are present following traumatic spinal cord injury (SCI), resulting in atrophy of the cervical cord of up to 30%. This study investigates the underlying biochemical changes at the cellular and molecular level which may subtend the development of atrophy using latest magnetic resonance spectroscopy in the spinal cord in healthy controls and SCI patients. Furthermore, we screen for potential MRS biomarkers investigating the association of biochemical changes and clinical outcome.

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