Abstract #0660

Real-time simultaneous shim and motion measurement and correction in CEST MRI using Double volumetric Navigators (DvNavs)

Gizeaddis L. Simegn¹, Andre J.W. Van der Kouwe^1,2,3, Borjan Gagoski^3,4, Frances Robertson^1,5, Ernesta Meintjes^1,5, and Ali Alhamud^1,5

¹MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa, ²Athinoula A. Martinos Center for Biomedical imaging/MGH, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ⁵Cape Universities Body Imaging Centre (CUBIC-UCT), Cape Town, South Africa

In Chemical Exchange Saturation Transfer (CEST) MRI, images are acquired by applying saturation RF pulses at multiple frequencies of small increments to generate the CEST-spectrum. This makes CEST sensitive to motion and field inhomogeneity. Several factors can also vary the shim prepared by the scanner. To date, no study has been conducted to evaluate and correct shim fluctuation during CEST acquisition. In this study, we implement CEST with Double volumetric Navigators (DvNavs) to evaluate and update in real-time motion, zero and first-order shim parameters. The results show the ability of the DvNavs to correct shim and motion during CEST acquisition.

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