Abstract #0637

Ketone measurement in human glioma following an Atkins-based diet

Adam Berrington^1,2, Karisa C Schreck³, Christopher T Whitlow⁴, Roy E Strowd⁵, and Peter B Barker^1,2

¹Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology, Wake Forest School of Medicine, Winston, NC, United States, ⁵Departments of Neurology and Oncology, Wake Forest School of Medicine, Winston, NC, United States

Recent studies have focused on the use of ketogenic diet (KD) in the treatment of glioma since tumor cells are heavily glucose-dependent. Here, we assess the ability of MRS to monitor KD-therapy in glioma patients. Using a semi-LASER sequence at 3 T, with fully simulated basis for spectral fitting, we measured increases in acetone and β-hydroxybutyrate after KD in tumor and contralateral brain. NAA concentration decreased in contralateral brain and there was an observed elevation of β-hydroxybutyrate in IDH-mutated gliomas; potentially indicating differential response to KD. These results indicate a potential for MRS in monitoring KD-based therapy in glioma.

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