Abstract #0633

Magnetic Resonance Angiography Reveals Increased Arterial Blood Supply and Tumorigenesis Following High Fat Feeding in a Mouse Model of Triple-negative Breast Cancer

Devkumar Mustafi¹, Rebecca Valek¹, Michael Fitch¹, Victoria Werner¹, Xiaobing Fan¹, Erica Markiewicz¹, Sully Fernandez², Marta Zamora¹, Jeffrey Mueller³, Suzanne D Conzen⁴, Matthew J Brady², and Gregory S Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, United States, ³Pathology, The University of Chicago, Chicago, IL, United States, ⁴Medicine, the Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States

Breast cancer is the most commonly diagnosed malignancy among women in the US. Epidemiology shows that a high animal fat diet increases risk of triple-negative breast cancer (TNBC). Our previous work examined the effect of pre-pubertal exposure to high dietary animal fat in the SV40Tag mouse model of TNBC. We showed that a high animal fat diet changes mammary fat composition and increases incidence and aggressiveness of mammary cancers in this model. Here, we demonstrate using MR angiography that changes in fat composition and cancer incidence are paralleled by increases in vascular density in the mammary gland.

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