Abstract #0622

Creatine Kinase Rate Constant in the Human Heart at 7T: A Novel Superfast Magnetization Saturation Transfer Method

Adil Bashir¹, Jianyi Zhang², Nouha Salibi³, Ronald Beyers⁴, and Thomas Denney¹

¹Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ²Department of Biomedical Engineering, University of Alabama Birmingham, Birmingham, AL, United States, ³Siemens Healthineers and AUMRI Center, Auburn, AL, United States, ⁴Auburn University, Auburn, AL, United States

Changes in Creatine Kinase (CK) system are observed in heart failure and measurement of CK reaction rate constant (kf) can be useful to monitor pathology. 7T MR scanner offers improved signal to noise and spectral resolution and has potential for robust measurements. In this study we demonstrate novel superfast saturation transfer method (T1nom – method) to measure ATP production rate via CK forward reaction in human hearts at 7T. Spatial localization was achieved by GOIA-1D-ISIS/2D-CSI approach. Our measured kf values were consistent with literature.

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