Abstract #0614

Observed MRI changes following Directly-Acting Antiviral Therapy in Hepatitis-C virus patients

Chris Bradley^1,2, Rob Scott², Eleanor F Cox^1,2, Naaventhan Palaniyappan², Neil Guha², Guru P Aithal², and Susan T Francis^1,2

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

Hepatitis C Virus (HCV) is globally the largest viral cause of mortality. Directly Acting Antiviral (DAA) therapy achieves >90% sustained virological response in HCV patients. We used multiparametric MRI to assess changes in hepatic angio-architecture after patients had DAA therapy. The time window between pre- and post-treatment scans was of 3-6 months. We observed changes in hepatic microstructure indicated by a reduction in liver T₁ (35±4ms), T₂ (2.5±0.8ms) and T₂* (3.0±0.7ms) which we suggest are linked to reduced pro-inflammatory milieu, including interstitial oedema, within the liver. No changes were observed in hepatic/splanchnic blood flow or perfusion.

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