Abstract #0606

PET-MRI Quantification of 89Zr-Iron Oxide Nanoparticles for Targeted Magnetic Drug Therapy

Caroline D. Jordan¹, Misung Han¹, Sravani Kondapavulur^1,2, Denis Beckford Vera¹, Kiel D. Neumann¹, Carol Stillson¹, Teri Moore¹, Roland Krug¹, Spencer Behr¹, Youngho Seo¹, Henry F. VanBrocklin¹, Peder E. Z. Larson¹, Mark W. Wilson¹, Alastair J. Martin¹, and Steven W. Hetts¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Bioengineering, University of California, Berkeley, Berkeley, CA, United States

One recent application of magnetic nanoparticles is to deploy an endovascular magnetic device to selectively remove magnetically-linked chemotherapy during an intra-arterial treatment procedure. In order to measure the device’s efficacy,⁸⁹Zr-iron oxide nanoparticles could be imaged using PET-MR. We measured quantitative susceptibility values (Δχ), R₂*, and ⁸⁹Zr-PET uptake of increasing concentrations of ⁸⁹Zr-IONP in vitro, and in liver in vivo by acquiring a multi-echo UTE GRE sequence and time-of-flight PET. Phantom evaluations demonstrated linear correlation between Δχ, R₂*, and ⁸⁹Zr-IONP uptake. In vivo, substantial increase was observed after ⁸⁹Zr-IONP infusion. This approach shows promise tracking the biodistribution of radiolabelled magnetic nanoparticles.

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