Resting-state functional connectivity alterations in adolescents with fetal alcohol spectrum disorders
Jia Fan1,2, Joseph L. Jacobson2,3,4, Christopher D. Molteno4, Sandra W. Jacobson2,3,4, and Ernesta M. Meintjes1,2
1MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, 2Department of Human Biology, University of Cape Town, Cape Town, South Africa, 3Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 4Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
In a study of children with fetal alcohol spectrum disorders (FASD) and community controls assessed at age 11 years, alcohol-exposed children showed localised dose-dependent reductions in resting state functional connectivity (FC) in 5 gray matter regions within 5 resting state networks. Here we present data from a follow-up study of these children at age 15 years to examine whether these FC deficits persist or resolve.
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