Abstract #0587

Compartmental brain sodium concentrations in human brain tissues in white matter and grey matter: a multi-echo ultra-high field 23Na-MRI study

Ben Ridley^1,2, Armin M. Nagel^3,4, Mark Bydder^1,2, Adil Maarouf^1,2, Jan-Patrick Stellmann^1,2, Soraya Gherib^1,2, Jeremy Verneuil^1,2, Patrick Viout^1,2, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, and Wafaa Zaaraoui^1,2

¹CRMBM, Aix-Marseille University, Marseille, France, ²CEMEREM, APHM Hôpitaux de la Timone, Marseille, France, ³Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁴German Cancer Research Centre, Division of Medical Physics in Radiology, Heidelberg, Germany

Using multi-echo ²³Na-MRI at 7T acquired in 13 healthy subjects and modelling the relationship between signal and reference concentration and applying it to in vivo ²³Na-MRI signal, we quantify both T2* decay times and concentrations associated with short and long components for the first time. Relaxation times and concentrations differed between grey and white matter and subregions of differing tissues, suggesting sensitivity of ²³Na toward features of tissue composition. As such, these results raise the prospect of multi-echo ²³Na-MRI as an adjunct source of information on biochemical mechanisms in both physiological and pathophysiological states.

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