Gadolinium(Gd)-stained MRI is based on Gd-contrast agent administration into the brain. This method significantly improves the detection of amyloid plaques, one of the lesions of Alzheimer's disease and a potential biomarker for its diagnosis. Here, we aimed to better understand the origin of contrast induced by amyloid plaques by determining critical parameters required for their detection using five mouse models of amyloidosis presenting with different plaque typologies. Then, we showed for the first time that Gd-stained MRI can detect amyloid plaques in postmortem human brain tissues and compared the detection achieved in mice with those obtained in human samples.
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