In 2006, Parker et al published a population-average AIF that has subsequently been used by numerous investigators for both simulation and data analysis. Despite its utility, the published AIF suffers from a number of limitations. In this study we tried to address many of these limitations and made measurements in a population of patients with advanced breast cancer, resulting in a total of 74 individual AIFs. We fitted each AIF with a physiological model and assessed inter- and intra-patient variability.
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