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Abstract #0514

Liver R2* as a Biomarker of Liver Iron Concentration: Interim Results from a Multi-Center, Multi-Vendor Reproducibility Study at 1.5T and 3T

Diego Hernando1,2, Ruiyang Zhao1,2, Valentina Taviani3, Mounes Aliyari Ghasabeh4, Li Pan5, Qing Yuan6, Stefan Ruschke7, Dimitrios C. Karampinos7, Xiaodong Zhong8, Ryan J. Mattison9, Ihab R. Kamel4, Ivan Pedrosa6, Shreyas Vasanawala10, Takeshi Yokoo6,11, and Scott B. Reeder1,2,9,12,13

1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, 4Radiology, The Johns Hopkins University, Baltimore, MD, United States, 5Siemens Healthineers, Baltimore, MD, United States, 6Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Radiology, Technical University of Munich, Munich, Germany, 8Siemens Healthineers, Los Angeles, CA, United States, 9Medicine, University of Wisconsin-Madison, Madison, WI, United States, 10Radiology, Stanford University, Stanford, CA, United States, 11Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 12Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 13Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

R2* is a promising biomarker of liver iron concentration (LIC), with application in the assessment of iron overload. Previous works have demonstrated the high correlation of liver R2* with biopsy-determined LIC. Although R2* measurements may be affected by multiple confounding factors, including the presence of fat and noise bias, confounder-corrected R2* mapping has been shown to be highly insensitive to the presence of these confounding factors. However, the multi-center reproducibility of confounder-corrected R2* for liver iron quantification remains unknown. This abstract demonstrates excellent reproducibility of R2* for liver iron quantification in a multi-center, multi-vendor study at both 1.5T and 3T.

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