Abstract #0495

The effects of diffusion on the tissue orientation dependent gradient echo dynamic susceptibility contrast signal

Jonathan Doucette^1,2, Enedino Hernández-Torres^1,3, Christian Kames^1,2, Luxi Wei⁴, and Alexander Rauscher^1,3,5

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Gradient echo dynamic susceptibility contrast (DSC) imaging of cerebral white matter tissue perfusion exhibits a strong dependency on the angle between white matter fibres and the main magnetic field. Here, we investigate the extent to which the diffusion of spins within the locally magnetically inhomogenous environment affects the orientation dependency of the DSC signal using a numerical model of the transverse magnetization within a voxel containing both isotropic and anisotropic vasculature. We found that diffusion increases the measured change in $$$R_2^*$$$ by up to an average of 3.2% for typical diffusion values, independent of fibre orientation, and further improves the fit between the simulated and measured $$$R_2^*$$$ values.

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