Abstract #0480

Estimation of a signal-appropriate reference volume to improve registration of high b-value diffusion volumes in the human placenta

Conrad P Rockel¹, Barbra de Vrijer^2,3, and Charles McKenzie^1,3

¹Medical Biophysics, Western University, London, ON, Canada, ²Dept of Obstetrics and Gynaecology, Western University, Ontario, ON, Canada, ³Division of Maternal, Fetal, and Newborn Health, Children's Health Research Institute, London, ON, Canada

A technique is presented to aid in better motion correction of high b-value diffusion images of the human placenta in utero for the purposes of quantification using intra-voxel incoherent motion (IVIM). A registration reference volume is calculated with signal intensities and tissue features with similarity to volumes with high diffusion weighting, and produce more successful registrations than when using the b=0 volume as a reference.

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