Abstract #0469

Longitudinal multi-component HARDI atlas of neonatal white matter

Maximilian Pietsch^1,2, Daan Christiaens^1,2, Jana Hutter^1,2, Lucilio Cordero-Grande^1,2, Anthony N Price^1,2, Emer Hughes¹, A. David Edwards¹, Joseph V. Hajnal^1,2, Serena J Counsell¹, and J-Donald Tournier^1,2

¹Centre for the Developing Brain, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department of Biomedical Engineering, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom

We describe a method for creating a longitudinal atlas of developing white matter (WM) of neonates using the multi-shell multi-tissue constrained spherical deconvolution technique and multi-contrast registration on high-quality high angular resolution diffusion imaging (HARDI) data. We present an atlas that consists of one isotropic and two orientationally-resolved components. The atlas reveals fibre-specific patterns of WM maturation that are consistent with regional differences in maturation previously described in histological studies of the developing brain.

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