Deep Brain Stimulation is an effective treatment for Parkinson's disease symptoms. Despite its success, the underlying principle and the mechanisms are not yet fully understood. In this study, we recorded concurrent DBS-fMRI to 1) elucidate brain regions activated at the clinically optimal settings and, 2) determine the effect of changes in stimulation frequency on whole-brain activation. Optimal DBS frequencies showed activation in the thalamus and motor cortices. Further, there was a significant difference in activation in the sensorimotor cortices between the optimal and non-optimal frequencies, indicating potential use for fMRI as a tool for optimizing DBS parameters.
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