Abstract #0417

CEST Fingerprinting: Initial Study in Human Subjects

Zhengwei Zhou¹, Qi Yang^1,2, Zhaoyang Fan¹, Pei Han¹, and Debiao Li^1,3

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, ³Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

CEST fingerprinting was recently proposed to achieve efficient exchange rate quantification for pH mapping. Here we present the initial data of pH mapping in healthy subjects and one acute stroke patient at clinical scanners in an 8-min scan using CEST fingerprinting. The pH maps of the healthy volunteers are homogenous and the values fall in the normal physiological range. The pH map in the patient shows an inhomogenous acidic area. This study shows CEST fingerprinting has the potential to detect acidosis in human subjects.

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