Abstract #0408

NOE-mediated CEST Imaging of Glioma at 7 Tesla Aids Early Response Evaluation of Patients Undergoing Radio-Chemotherapy

Jan-Eric Meissner¹, Sebastian Regnery², Andreas Korzowski¹, Steffen Goerke¹, Jürgen Debus², Heinz-Peter Schlemmer³, Mark E. Ladd¹, Peter Bachert¹, Sebastian Adeberg², and Daniel Paech³

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Radiation Oncology, Medical Faculty, University of Heidelberg, Heidelberg, Germany, ³Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Reliable biomarkers for an early assessment of treatment response are urgently needed. In this study, we investigated the rNOE-mediated CEST signals in patients undergoing radio- and chemotherapy at three different time points including pre and post treatment. The results were compared to the standard clinical determination of responders and non-responders (RANO criteria) and the relaxation compensated CEST contrast NOE_AREX showed a statistically significant difference between the two groups directly after therapy. Hence, NOE_AREX might potentially help determining early tumor response to therapy.

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