The mechanisms that influence metastatic growth rates are poorly understood. One mechanism of interest known as concomitant tumor resistance (CTR) can be defined as the inhibition of metastatic growth by existing tumor mass. Conversely, the presence of a primary tumor has also been shown to increase metastatic outgrowth, termed concomitant tumor enhancement (CTE). The goal of this research was to use conventional and cellular MRI , and bioluminescence imaging to study the impact of a primary tumor on the development of breast cancer brain metastases in a syngeneic mouse model.
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