Abstract #0384

Synthetic MP2RAGE: multiple ‘on-demand’ contrasts from a single acquisition

Aurélien Massire^1,2, Thomas Troalen³, Olivier M Girard^1,2, Tobias Kober^4,5,6, Bénédicte Maréchal^4,5,6, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, and Virginie Callot^1,2

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Siemens Healthcare SAS, Saint-Denis, France, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁶Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

MP2RAGE and FLAWS sequences are increasingly used for brain clinical research imaging at ultra-high field. Yet, the ability to provide at the same time an optimal contrast between GM and WM for segmentation, an accurate T₁ mapping and/or the ability to highlight only a single tissue or lesions, is in practice not possible with only one single MP2RAGE acquisition. In this work, we demonstrate that synthetic ‘uniform’ images with ‘on-demand’ clinically relevant contrasts could be generated at 7T from a single MP2RAGE acquisition providing an accurate T₁ map, allowing for instance tissue signal nulling or lesion signal enhancement.

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