Abstract #0369

Macromolecular proton fraction closely correlates with myelin loss in the rat ischemic stroke model

Alena A Kisel¹, Marina Yu Khodanovich¹, Dmitriy N Atochin^1,2, Andrey E Akulov^1,3, Lilia R Mustafina⁴, Anna V Naumova^1,5, and Vasily L Yarnykh^1,5

¹Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation, ²Massachusetts General Hospital, Charlestown, MA, United States, ³Institute of Cytology and Genetics SB RAS, Novosibirsk, Russian Federation, ⁴Siberian State Medical University, Tomsk, Russian Federation, ⁵Department of Radiology, University of Washington, Seattle, WA, United States

Non-invasive quantitative assessment of myelin damage in ischemic stroke is currently unavailable. The goal of this study was to evaluate a recently proposed myelin imaging technique, macromolecular proton fraction (MPF) mapping in the rat stroke model and compare it with histological myelin quantitation. MPF decrease in the brain infarct closely correlated (R = 0.81, p<0.001) with luxol fast blue staining on the 1st, 3rd, and 10th day after stroke. Further improvement in accuracy of myelin quantitation (R = 0.98) was achieved with the use of bivariate linear regression model including T₂ to correct errors related to edema.

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