Studies of bone marrow adipose tissue (bMAT) composition in osteoporosis has revealed increased [a1] in fat content and decreased unsaturated fatty acid in the proximal femur in osteoporosis (OP) patients compared to controls. Advancements in MR image-based methods for fat assessment have allowed quantification of fat content though chemical-shift encoded MRI (CSE-MRI). CSE-MRI methods have not been compared to MRS for bMAT composition assessment. The aim of this study was to quantify, within subregions of the proximal femur, bone marrow PDFF as well as saturated and unsaturated fat using both CSE-MRI and MRS.
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